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Effect of QRDR mutation in M. smegmatis GyrA on FQ binding. (A) Binding of CFX and MFX to the M. smegmatis DNA gyrase (MsGyr) reconstituted using wild-type (WT) or D94G GyrA. (B) Interaction of FQs with wild-type (WT) and D94G MsGyrA subunit. A 10 nM concentration of each of the FQs and a 50 nM concentration of the holoenzyme or the GyrA subunit were used.
