TABLE 3.
Pooled MIC distributions of voriconazole for 12 Candida species
| Species | No. of labsa | No. of isolates | No. of isolates for which the MIC (μg/ml) wasb: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.008 | 0.016 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | |||
| C. albicans | 9c | 3,210 | 105 | 1,768 | 670 | 291 | 140 | 114 | 84 | 21 | 11 | 2 | 4 |
| C. dubliniensis | 7 | 152 | 52 | 86 | 7 | 3 | 2 | 1 | 1 | ||||
| C. glabrata | 11 | 4,176 | 13 | 208 | 556 | 1,476 | 983 | 304 | 166 | 162 | 172 | 112 | 24 |
| C. guilliermondii | 12 | 369 | 3 | 42 | 126 | 119 | 33 | 20 | 12 | 8 | 1 | 3 | 2 |
| C. krusei | 12 | 930 | 1 | 8 | 36 | 136 | 476 | 207 | 53 | 12 | 1 | ||
| C. lusitaniae | 8c | 142 | 23 | 61 | 51 | 6 | 1 | ||||||
| C. parapsilosis | 8c | 2,337 | 188 | 986 | 547 | 334 | 119 | 80 | 46 | 26 | 11 | ||
| C. tropicalis | 8c | 3,127 | 547 | 912 | 893 | 441 | 155 | 69 | 43 | 31 | 21 | 8 | 7 |
| C. famata | 9 | 53 | 6 | 10 | 23 | 10 | 3 | 1 | |||||
| C. kefyr | 7 | 34 | 4 | 17 | 11 | 1 | 1 | ||||||
| C. orthopsilosis | 4 | 66 | 9 | 30 | 17 | 9 | 1 | ||||||
| C. rugosa | 9 | 59 | 1 | 6 | 34 | 12 | 3 | 3 | |||||
a
Number of laboratories contributing data to each MIC distribution.
b
MICs determined at 24 h as described in the CLSI M27-A3 reference method (17). The modal MIC (most frequent value) for each distribution is underlined.
c
Data from 1 to 7 labs were not used due to abnormal MIC distributions (the mode and lowest concentration tested were the same).