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Multidose exposure-efficacy relationship of amphotericin B against each Aspergillus species with modal CLSI MICs of 1 mg/liter for A. fumigatus, A. flavus, and A. terreus in the in vitro PK-PD model simulating amphotericin B human serum levels based on the increasing amphotericin B fCmax (maximum concentration) and the galactomannan index as a marker of fungal growth.
