FIG 7.
Kinetics and inhibition of L. mexicana microsomal OSC. (A) Double-reciprocal plot of LmOSC enzyme activity as a function of the [2,3-14C]oxidosqualene concentration in the presence of the different fixed concentrations of dronedarone. (Inset) Plot of the intercepts as a function of the dronedarone concentration which yields a Ki value of ∼0.7 μM. Activity was measured in the presence of 0.1% Triton X-100. (B) Effects of dronedarone on the activity of L. mexicana microsomal OSC in the presence of saturating substrate concentrations.