FIG 2.
Isavuconazole is as effective as high-dose LAmB in improving survival (A) and reducing fungal burden (B) of neutropenic mice from mucormycosis. Mice (n = 10 per arms for both A and B) were infected intratracheally with 2.5 × 105 spores of R. delemar 99-880 (average inhaled inoculum was 1.3 × 103 cells). Isavuconazonium sulfate (215 mg/kg t.i.d., by oral gavage) or LAmB (15 mg/kg every day by i.v. injection) treatment started 8 h postinfection and continued through day 4 postinfection (A) and day 3 postinfection (B). Placebo mice were infected and treated with 5% dextrose water. (A) Survival of mice through day 21. *, P = 0.025 or 0.004 for LAmB or ISA compared to placebo by log rank test, respectively. (B) Fungal burden was measured by qPCR with a conidial standard curve (29, 34). All qPCR results are expressed as log10 spore equivalents per gram of tissue. *, P < 0.05 compared to placebo by Wilcoxon rank sum test.