TABLE 1.
In vitro activities of six antifungal agents and GS inhibition profiles for echinocandin drugs against five C. glabrata isolates harboring FKS mutations
| Strain/mutation | FKS2 hot spot genotype | MIC (mg/liter) for: |
IC50 (ng/ml) for: |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMB | FLC | VRC | ANF | CSF | MCF | ANF | CSF | MCF | ||
| ATCC 90030 | FKS1/FKS1 (wild type) | 0.25 | 4 | 0.03 | 0.06 | 0.03 | 0.03 | 46.1 | 29.7 | 15.29 |
| 8622 A | fks1/fks1 (S663F) | 0.25 | >64.0 | 4.0 | 1.0 | 1.0 | 0.5 | 2,655 | 1,263 | 61,760 |
| 8622 B | fks1/fks1 (S663F) | 0.25 | >64.0 | 4.0 | 1.0 | 1.0 | 0.5 | NDa | ND | ND |
| 8622 C | fks1/fks1 (S663F) | 0.25 | >64.0 | 4.0 | 1.0 | 1.0 | 0.5 | ND | ND | ND |
| 8622 D | fks1/fks1 (S663F) | 0.25 | >64.0 | 4.0 | 1.0 | 1.0 | 0.5 | ND | ND | ND |
| 8622 E | fks1/fks1 (S663F) | 0.25 | >64.0 | 4.0 | 1.0 | 1.0 | 0.5 | ND | ND | ND |
a
ND, not determined.