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. 2014 Apr;58(4):2067–2075. doi: 10.1128/AAC.00617-13

FIG 2.

FIG 2

Parasitemia curves of T. cruzi-infected mice treated i.v. with lychnopholide at 2.0 mg/kg/day and benznidazole at 50 mg/kg. (A) Mice infected with CL strain treated with 10 doses (started 24 h after infection). (B) Mice treated with 20 doses (started in the prepatent period [day 7 after infection]). (C) Mice infected with Y strain treated with 10 doses (started 24 h after infection). (D) Mice treated with 20 doses (started in the prepatent period [day 4 after infection]). dpi, days postinfection; LYC-PCL NC, lychnopholide loaded in conventional NC; LYC-PLA-PEG NC, lychnopholide loaded in PEG sterically stabilized NC; free LYC, lychnopholide in i.v. solution; BZ, benznidazole i.v. solution; control groups, untreated (infected and not treated) or Un-NC (unloaded NC); control solution, DMA-PEG 300.