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. 2014 Mar;34(5):877–887. doi: 10.1128/MCB.00360-13

FIG 7.

FIG 7

Impaired learning and memory in daDREAM mice. (A) Escape latency across acquisition sessions (A1 to A10) is increased in transgenic (tg, n = 11) with respect to wild-type (wt, n = 10) mice [repeated-measures ANOVA, F(1,19) = 9.052, P = 0.007]. (Inset) No difference in swimming speed was detected between genotypes [repeated-measures ANOVA, F(1,19) = 3.633, P = 0.072]. (B and C) In the repeated reversal learning paradigm, transgenic mice (n = 10) showed increases in escape latency in odd (B) and even (C) trials, related to impairment in reference and working memory, respectively, across the eight acquisition sessions (A1 to A8), compared to the results for wild-type mice (n = 10). Data are expressed as means ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001. For statistical details, see Table S7 in the supplemental material.