Table 6. Overall analysis of complications comparing LRC and ORC.

Outcome of interest	No. of studies	No. of patients, LRC/ORC	OR (95% CI)	p-value	Study heterogeneity				Egger’s test (p value)
					Chi2	df	I2	p-value
Overall complications	12	456/434	0.60 [0.44, 0.80]	<0.001	11.10	11	1%	0.43	0.50
Major complications	12	456/434	1.04 [0.69, 1.55]	0.86	8.07	11	0%	0.71	0.28
Minor complications	12	456/434	0.45 [0.33, 0.62]	<0.001	18.39	11	40%	0.07	0.11
1. Infectious disease	11	406/384	0.31 [0.20, 0.49]	<0.001	9.80	10	0%	0.46	0.52
Wound infection	8	323/304	0.24 [0.10, 0.57]	0.001	3.36	7	0%	0.85	0.23
Pulmonary infection	7	334/299	0.31 [0.14, 0.69]	0.004	0.26	6	0%	1.00	0.10
UTI	9	381/348	0.76 [0.40, 1.44]	0.40	5.05	8	0%	0.88	0.92
GI infection	3	88/81	0.35 [0.08, 1.55]	0.17	2.06	2	3%	0.36	0.50
Systemic sepsis	3	115/105	0.15 [0.03, 0.87]	0.03	0.40	2	0%	0.82	0.11
2. Wound Dehiscence	6	182/188	0.64 [0.21, 1.92]	0.43	2.11	5	0%	0.83	0.02
3. Neurologic	3	81/76	0.86 [0.24, 3.05]	0.82	2.16	2	7%	0.34	0.06
4. Renal fistula/leak	7	291/269	0.63 [0.31, 1.27]	0.19	3.01	6	0%	0.81	0.92
5. Ureteric obstruction	4	229/189	1.90 [0.79, 4.54]	0.15	4.89	4	18%	0.30	0.48
6. GI fistula/leak	5	246/201	1.17 [0.39, 3.52]	0.78	3.43	4	0%	0.49	0.50
7. Ileus	10	399/376	0.54 [0.31, 0.94]	0.03	7.37	9	0%	0.60	0.45
8. Thromboembolic DVT/PE	5	174/164	0.43 [0.14, 1.35]	0.15	1.78	4	0%	0.75	0.17

CI = Confidence interval; OR, odds ratio; LRC =  laroscopic radical cystectomy; ORC =  open radical cystectomy; UTI = urinary tract infection;

GI = gastrointestinal; DVT =  deep vein thrombosis; PE = pulmonary embolus.

*Statistically significant results are shown in bold.