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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Biomaterials. 2014 Apr 4;35(20):5327–5336. doi: 10.1016/j.biomaterials.2014.03.034

Figure 5. Action potentials of iNs generated on smooth substrates and 5 μm gratings.

Figure 5

(A) A representative trace of a train of action potentials in response to step depolarizing current injection of a synapsin-RFP+ iN on smooth substrate. (B) A train of action potentials in synapsin-RFP+ iN on 5 μm gratings in response to depolarizing current injection. (C) No difference was observed in membrane capacitance between iNs on smooth or grating substrates. (D) The input resistance of iNs on 5 μm gratings was slightly lower compared to iNs on smooth substrates. (E) A representative trace of fluorescent intensity measurements in iN on smooth and (F) on grating substrates in response of KCl and glutamate stimulation. (G) Image sequence of a representative iN (arrow) before stimulation, stimulated with KCl, between stimulations and stimulated with glutamate. Warm colors white, yellow and red represent high fluorescent intensities. Scale bar 10 μm.