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. 2014 May 16;9(5):e97249. doi: 10.1371/journal.pone.0097249

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© 2014 Buness et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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All measurements are visualized in detail for the 1–2 best ranked markers for each type of parameter (subfigure A: clinical chemistry in serum, B: metabolite in liver tissue, C: metabolite in serum, D/E: transcript in liver tissue). The fold-change of each sample is calculated with respect to the matching control group (vehicle treatment). The mean of each class is shown as horizontal line (black: negative including controls, yellow: increased in ALT or AST, red: positive). The size of the treatment symbols increase with dose. The time points are resolved by aligning the symbols in columns.