Figure 2. Parity-associated risk factors for UTI in aged hosts.

Bladder CFU for UPEC (A) and GBS (C), and kidney CFU for UPEC (B) and GBS (D) at 24 hours post infection of C3H/HeN female mice with ∼10⁷ UPEC UTI89 alone or with ∼10⁷ GBS COH1 in UPEC+GBS mixed inoculation. N = 1–4, at least 5 mice per experiment, as described for Fig. 1. Data from 7–11 mo (aged) nulliparous animals are replotted from Fig. 1 here for ease of comparison with data from aged multiparous hosts. The horizontal bar represents the median value for each group of mice. Statistical significance was determined by the Kruskal-Wallis test with Dunn’s post-test for multiple comparisons. * P<0.05, *** P<0.0005.