Table 2. Mechanical 3-point bending tests of mouse femora demonstrated reduced ductility in Osx-Cre cKO mice.
| Group | Genotype | Gender | Age(wk) | Numbermice | Average corticalthickness (mm) | Bone Area(mm2) | Distance from centerof mass (c) (mm) | Energy at ultimateforce (N*mm) | Energy at fractureforce (N*mm) |
| Osx-Cre WT | BMP2 fl/fl;Osx-Cre− | Males | 24 | 4 pairs | 0.254±0.02 | 1.02±0.12 | 0.73±0.11 | 6.971±1.0 | 10.39±2.70 |
| Osx-Cre cKO | BMP2 fl/fl;Osx-Cre+ | Males | 24 | 3 pairs | 0.236±0.03 | 0.799±0.20 | 0.603±0.07 | 3.798±2.5 | 4.21a ±2.85 |
| Osx-Cre WT | BMP2 fl/fl;Osx-Cre− | Males | 12 | 5 pairs | 0.251±0.02 | 0.987±0.15 | 0.686±0.09 | 6.308±2.6 | 10.73±4.63 |
| Osx-Cre cKO | BMP2 fl/fl;Osx-Cre+ | Males | 12 | 4 pairs | 0.226±0.03 | 0.714a ±0.06 | 0.575a ±0.02 | 2.760a ±0.62 | 3.88a ±0.63 |
| Osx-Cre 1/2 cKO | BMP2 fl/+;Osx-Cre+ | Males | 12 | 8 pairs | 0.232±0.03 | 0.835b ±0.06 | 0.631±0.03 | 4.711±1.3 | 7.95±3.28 |
a
p<0.05 WT v. cKO, b p<0.05 WT v. 1/2 cKO (same ages).
*p<0.05 12wk v 24 wk (same genotype).