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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Hum Genet. 2014 Jan 5;133(6):701–711. doi: 10.1007/s00439-013-1413-1

Figure 1. Illustration of grammatical rules and their effect on gene expression.

Figure 1

Transcriptional grammar. The rules of transcription regulation are illustrated as “grammar cards”. Each card represents a different rule. For example, the number of binding sites for the same TF, the distance of one TF from the TSS, the orientation of the binding-site relative to the TSS, etc.

Expression function. The function by which each rule affects expression. For example: cooperative binding results in a sigmoidal curve since one binding event increases the probability of another binding to occur, resulting in higher expression. The x-axis changes according to the rule identity. For example, for the rule of binding-site location, the x-axis represents distance from the TSS (in bp).