Table 2.
A comparison of the 15 proteins that were found to contain significant clustering via GraphPAC , iPAC or NMC
| |
GraphPAC
|
iPAC
|
NMC
|
|||
|---|---|---|---|---|---|---|
| Protein | p-value | p* | p-value | p* | p-value | p* |
| KRAS |
4.21 E-233 |
4.33 E-229 |
6.17 E-185 |
6.35 E-181 |
4.39 E-233 |
4.52 E-229 |
| TP53 |
4.05 E-152 |
4.48 E-147 |
5.23 E-128 |
6.11 E-123 |
4.37 E-086 |
5.30 E-081 |
| BRAF |
3.84 E-130 |
1.04 E-126 |
3.73 E-130 |
1.01 E-126 |
3.84 E-130 |
1.04 E-126 |
| PIK3CA |
8.20 E-084 |
3.58 E-080 |
8.20 E-084 |
3.58 E-080 |
8.20 E-084 |
3.58 E-080 |
| NRAS |
8.26 E-029 |
9.91 E-027 |
5.38 E-026 |
6.46 E-024 |
8.26 E-029 |
9.91 E-027 |
| HRAS |
1.54 E-014 |
6.94 E-013 |
1.23 E-010 |
5.54 E-009 |
5.61 E-010 |
8.42 E-009 |
| AKT1 |
2.47 E-005 |
2.47 E-004 |
1.18 E-005 |
7.08 E-005 |
2.47 E-005 |
7.41 E-005 |
| IDE |
1.56 E-003 |
4.67 E-003 |
2.20 E-005 |
6.60 E-005 |
1.56 E-003 |
4.67 E-003 |
| EGFR |
9.04 E-004 |
9.04 E-003 |
1.35 E-004 |
1.35 E-003 |
- |
- |
| DPP4 |
3.17 E-003 |
3.63 E-002 |
- |
- |
- |
- |
| MAP2K4 |
1.21E-003 |
1.21E-002 |
- |
- |
- |
- |
| NRP1 |
1.58E-002 |
1.58E-002 |
- |
- |
- |
- |
| PCSK9 |
5.61 E-003 |
1.68E-002 |
- |
- |
- |
- |
| HAO1 |
- |
- |
7.95 E-003 |
2.39 E-002 |
- |
- |
| EIF2AK2 | - | - | 2.45 E-003 | 7.36 E-003 | - | - |
If a specific method did not find a particular protein to contain significant clustering, a "-" is shown. The p* calculation is described in Section ‘Multiple comparison adjustment for structures’. The smallest p-value from all of the insertion methods was selected.