Table 4.
A comparison of GraphPAC and NMC identified clusters for the BRAF structure
|
(a) Clusters found by
GraphPAC
| ||||
|---|---|---|---|---|
| |
p-value |
|||
| Start | End | # Muts. | GraphPAC | NMC |
| 600 |
600 |
60 |
2.12E-129 |
2.12E-129 |
| 597 |
600 |
62 |
1.49E-104 |
1.49E-104 |
| 600 |
601 |
62 |
1.49E-104 |
9.22E-117 |
| 596 |
600 |
64 |
7.16E-102 |
7.16E-102 |
| 596 |
601 |
66 |
3.37E-91 |
1.16E-100 |
| 597 |
601 |
64 |
8.07E-91 |
7.16E-102 |
| 601 |
671 |
3 |
5.85E-38 |
- |
| 600 |
671 |
63 |
8.30E-37 |
7.08E-26 |
| 469 |
601 |
72 |
2.59E-22 |
5.92E-17 |
| 581 |
601 |
68 |
1.23E-21 |
1.33E-65 |
| 581 |
600 |
66 |
2.94E-20 |
3.13E-63 |
| 469 |
600 |
70 |
3.98E-20 |
4.91E-15 |
| 466 |
601 |
74 |
2.15E-17 |
9.69E-19 |
| 466 |
600 |
72 |
7.01E-16 |
1.60E-16 |
| 464 |
601 |
75 |
1.15E-15 |
1.12E-19 |
| 464 |
600 |
73 |
2.33E-14 |
2.97E-17 |
|
(b) Clusters found by
NMC
and dropped by
GraphPAC
| ||||
|
Start |
End |
# Muts. |
|
NMC
Pvalue |
| 596 |
671 |
67 |
|
4.12E-29 |
| 597 |
671 |
65 |
|
4.79E-27 |
| 581 |
671 |
69 |
|
3.33E-26 |
| 464 |
671 |
76 |
|
5.92E-09 |
| 466 |
671 |
75 |
|
3.32E-08 |
| 469 | 671 | 73 | 8.11E-07 | |
A "-" for the NMC value signifies that cluster was not identified under the linear algorithm.