Fig. 1.

In vitro cytotoxicity of LTX-315, B16 melanoma cell cytocide kinetics and in vitro cytotoxicity of LTX-315 versus chemotherapeutic drugs. The in vitro cytotoxicity of LTX-315 and LTX-328 against a selection of cancer cell lines and normal cell lines (a). Cell killing kinetics of LTX-315 (IC₁₀₀) against B16F1 melanoma cells (b) after designated time points (5, 15, 30, 45, 60, 90 and 120 min). IC₁₀₀ of LTX-315 = 35 μM. In vitro cytotoxicity data demonstrating IC₅₀ values of LTX-315 (red line) and three different chemotherapeutic drugs (c), dacarbazine (filled squares), temozolomide (filled triangles) and cisplatin (filled reverse triangles) after designated time points (2, 4, 8, 24 and 48 h). The four compounds were tested against a murine B16F1 and a human A375 melanoma cell line. Data from three experiments are presented for each time point as mean ± SEM