Table 1.
Melphalan pharmacokinetic parameters and extraction efficiency
| Parameters and efficiency | AUC (min * ng/mL) | Efficiency (%) | C max (ng/mL) | ||||
|---|---|---|---|---|---|---|---|
| Prefilter | Postfilter | Systemic | [(pre − post)/pre × 100] | Prefilter | Postfilter | Systemic | |
| Mean | 331,933 | 3,171 | 7,921 | 99.0 | 10,072 | 91 | 265 |
| SD | 56,039 | 873 | 5,809 | 0.4 | 1,762 | 26 | 257 |
| Minimum | 262,485 | 2,266 | 3,871 | 98.5 | 8,510 | 54 | 101 |
| Median | 333,548 | 3,113 | 4,721 | 99.0 | 9,525 | 102 | 128 |
| Maximum | 415,215 | 4,307 | 17,912 | 99.5 | 13,400 | 119 | 751 |
AUC area under the concentration–time curve
n = 6 animals