Table 1.

Epididymal fat weight of 3xTgAD and non-Tg mice in response to a high-fat diet

	Non-Tg		3xTgAD
	Control	High-fat	Control	High-fat
3–4 mo	0.50 ± 0.04	1.46 ± 0.12a	0.37 ± 0.02	1.00 ± 0.09a,c
7–8 mo	0.55 ± 0.08	1.62 ± 0.09a	0.50 ± 0.04	2.51 ± 0.36a,b
11–12 mo	0.73 ± 0.11	1.50 ± 0.09	0.54 ± 0.05	4.75 ± 0.59a,c
15–16 mo	1.21 ± 0.14	1.35 ± 0.27	0.67 ± 0.09	5.56 ± 0.85a,c

Mice were maintained on a high-fat or control diet and separate groups of mice were monitored until the age of 3–4, 7–8, 11–12, or 15–16 months when epididymal fat pad weight (g) was assessed. Data are mean ± SEM, n = 6–12/group. ^ap < 0.001 versus control fed mice of same genotype and ^bp < 0.01, ^cp < 0.001 versus non-Tg mice on the same diet. Two-way ANOVA with Bonferroni post hoc analysis.

Key: ANOVA, analysis of variance; SEM, standard error of the mean.