Table 1.

Summary of blood transcriptional profiling studies in tuberculosis. HC, healthy controls; LTB, latent tuberculosis; OD, other diseases; PBMC, peripheral blood mononuclear cells; TB, tuberculosis; TLR, Toll-like receptors. Modified from Berry et al. [67].

geographical region	year	sample	study design	key pathways	reference
South Africa, Malawi	2013	whole blood	TB versus OD TB versus LTB (HIV positive and negative)	—	[49]
UK	2013	whole blood	TB versus OD TB treatment	interferon signalling, role of pattern recognition receptors, antigen presentation	[16]
South Africa	2013	whole blood	TB treatment	complement; B-cell markers; CD64	[48]
Germany	2012	whole blood	TB versus OD	interferon signalling; complement; TLR signalling; Fcγ-receptor-mediated phagocytosis	[47]
South Africa	2012	whole blood	TB treatment	—	[25]
Indonesia	2012	PBMC	TB versus HC TB treatment	interferon signalling	[17]
The Gambia	2011	whole blood	TB versus LTB	JAK–STAT pathway; interferon signalling; TLR	[46]
USA and Brazil	2011	whole blood	TB versus LTB versus HC	interferon signalling	[45]
South Africa	2011	whole blood	TB versus LTB versus HC	—	[44]
UK and South Africa	2010	whole blood	TB versus LTB versus HC TB versus OD TB treatment	interferon signalling	[15]
South Africa	2007	whole blood	TB versus LTB	—	[43]
Germany	2007	PBMC	TB versus LTB	—	[42]