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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Clin Cancer Res. 2014 Mar 14;20(10):2595–2606. doi: 10.1158/1078-0432.CCR-13-2407

Figure 1.

Figure 1

Regulation of the Warburg effect by FOXM1. A, RT-PCR analysis of the mRNA expression for glycolytic enzymes in PANC-1 cells after knockdown of FOXM1 expression. Expression of PGK-1 and LDHA was significantly downregulated. β-actin and α-tubulin were used as controls. B, RT-PCR analysis of the mRNA expression for FOXM1, LDHA, LDHB, and PGK-1 in PA-TU-8902 and MDA Panc-28 cells after knockdown of FOXM1 expression. C, Western blot analysis of FOXM1, LDHA, and LDHB expression in pancreatic cancer cells. D, analysis of the lactate production in pancreatic cancer cell lines using a Lactate Assay Kit. E, analysis of the LDH activity in pancreatic cancer cell lines using a Lactate Dehydrogenase Activity Assay Kit.

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