Table 1.
Pre-treatment characteristics and originating site of the study population stratified by starting regimen.
| Ritonavir-boosted lopinavir (LPV/r) based | Efavirenz (EFV) based | |||||||
|---|---|---|---|---|---|---|---|---|
| ABC/3TC | d4T/3TC | p | ABC/3TC | d4T/3TC | p | |||
| Pre-treatment Characteristics | N | 855 | 3514 | 681 | 4493 | |||
| Age at ART initiation in months | N median (IQR) | 855 7 (4;18) | 3514 10 (5;21) | 0.043 | 681 96 (63;129) | 4493 81 (55;112) | <0.0001 | |
| Male Gender | N (column %) | 427 (50) | 1741 (50) | 0.84 | 337 (49) | 2298 (51) | 0.42* | |
| Pre-treatment CD4 cells/mm3 | N median (IQR) | 574 766 (315;1349) | 2488 662 (319;1158) | 0.0006 | 517 294 (115;529) | 3195 294 (131;522) | 0.44 | |
| Pre-treatment CD4 % | N median (IQR) | 564 18.8 (12.2;27.1) | 2478 16 (10.2;23.0) | <0.0001 | 496 13.8 (6.9;20.2) | 3087 11.5 (6.3;16.3) | <0.0001 | |
| Weight for age Z-score | N median (IQR) | 641 −2.4 (−3.6;−1.0) | 2683 −2.5 (−3.9;−1.3) | 0.030 | 397 −1.3 (−2.1;−0.5) | 2889 −1.5 (−2.4;−0.7) | 0.019 | |
| Height for age Z-score | N median (IQR) | 508 −2.3 (−3.5;−1.2) | 2330 −2.7 (−3.9;−1.5) | 0.0005 | 478 −2.1 (−2.8;−1.3) | 3179 −2.2 (−3.0;−1.4) | 0.039 | |
| Pre-treatment Viral Load (VL) log10 | N median (IQR) | 522 6.0 (5.3;6.5) | 2249 5.8 (5.1;6.3) | 0.0004 | 447 5.1 (4.5;5.5) | 2878 5.0 (4.4;5.5) | 0.062 | |
| <100,000 copies/ml | N (column %) | 96 (18) | 468 (21) | 0.22 | 202 (45) | 1501 (52) | 0.0061* | |
| Site | ||||||||
| Gugulethu | N (row %) | 12 (10) | 109 (90) | 0.0002 | 36 (16) | 193 (84) | 0.32* | |
| Harriet Shezi | N (row %) | 375 (22) | 1360 (78) | 345 (13) | 2346 (87) | |||
| Khayelitsha | N (row %) | 55 (15) | 317 (85) | 55 (13) | 358 (87) | |||
| RMMCH | N (row %) | 141 (17) | 704 (83) | 157 (15) | 919 (85) | |||
| Red Cross | N (row %) | 175 (22) | 627 (78) | 58 (12) | 418 (88) | |||
| Tygerberg | N (row %) | 97 (20) | 397 (80) | 30 (10) | 259 (90) | |||
Abbreviations: Stavudine (d4T), lamivudine (3TC), abacavir (ABC), antiretroviral treatment (ART).
*
Chi-square tests used to compare proportions. All continuous variable comparisons were done using t-tests if normally-distributed or Wilcoxon tests if not normally-distributed. RMMCH: Rahima Moosa Mother and Child Hospital.