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Examples of lncRNAs with roles in malignant hematopoiesis
| Name | Cell type | Loss of function molecular phenotype | Loss of function malignant phenotype | Functional assays | Reference |
|---|---|---|---|---|---|
| DLEU2 | B cells | Dysregulated cell cycle progression and apoptosis | MBL, CLL, DLBCL | Mouse knockout models; ectopioc expression | [58] |
| Xist | HSC | Compromised X inactivation; impaired maturation; loss of long-term HSCs | Mixed MPN/MDS | Mouse knockout models; transplantation assays | [72] |
