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. Author manuscript; available in PMC: 2015 May 20.
Published in final edited form as: J Am Coll Cardiol. 2014 Mar 19;63(19):2037–2045. doi: 10.1016/j.jacc.2014.01.067

Figure 1. Heterogeneities in the appearance of the epicardial action potential second upstroke gives rise to fractionated epicardial electrogram (EG) activity in the setting of Brugada syndrome (BrS).

Figure 1

Left panel: Shown are right precordial lead recordings, unipolar and bipolar EGs recorded form the right ventricular outflow tract of a BrS patient (from Nademanee et al. (11), with permission). Right panel: ECG, action potentials from endocardium (Endo) and two epicardial (Epi) sites, and a bipolar epicardial EG (Bipolar EG) all simultaneously recorded from a coronary-perfused right ventricular wedge preparation treated with NS5806 (5 μM) and verapamil (2 μM) to induce the Brugada phenotype. Basic cycle length=1000 ms.