Table 4.

RNA-binding proteins containing PrLDs that have been linked to degenerative disease

Protein	Alberti algorithm		PAPA analysis		Disease
	PrLD Ranka	PrLD amino acids	PAPA score	Highest scoring segment (isoform)b
TDP-43	43	277–414	0.042	339–414	ALS, FTLD
FUS	12	1–237	0.109	21–121 (2)	ALS, FTLD
TAF15	22	1–152	0.127	12–92 (2)	ALS, FTLD
EWSR1	25	1–280	0.057	194–274 (1)	ALS, FTLD
hnRNPA2B1	32	197–353	0.043c	241–321 (A2)	IBMPFD
hnRNPA1	38	186–372	0.093d	257–337 (b)	ALS, IBMPFD
TIA1	53	292–386	0.131	269–349 (1)	Welander distal myopathy

^aPrLD rank among the human genome [21]

^bSome of the proteins have multiple isoforms that differ either in their PAPA scores or the exact location of the highest scoring region. Shown are the amino acid positions for the highest scoring segments from the highest scoring isoform, with the isoform indicated in parentheses

^cThe PAPA score for the disease-associated mutant is 0.088

^d PAPA score for Isoform B, the highest scoring isoform. hnRNPA1 has two isoforms with substantially different PAPA scores. The IBMPFD-associated mutation increases the PAPA score of Isoform B to 0.125. Isoform A scores 0.041, but the IBMPFD-associated mutation increases the PAPA score to 0.087