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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Clin Cancer Res. 2014 Mar 14;20(10):2740–2750. doi: 10.1158/1078-0432.CCR-13-2507

Figure 6. Network analysis of angiogenesis factors differentially regulated by 3G3 treatment in PDGFRa- positive cells (HEC-1A) and PDGFRa-negative cells (RL95-2).

Figure 6

Netwalker analysis showed that angiogenesis factors (e.g., VEGFA, HADC7, ITG, and VCAN) were down-regulated by 3G3 treatment in PDGFRa-positive cells, but not in PDGFRa-negative cells. Coloring is based on the log-ratio of expression levels for 3G3+PDGF-AA treatment over PDGF-AA treatment. Gene-expression differences were considered statistically significant if the P values were less than 0.001. A stringent significance threshold was used to limit the number of false-positive findings.