Table 2.
The percent microdissected targets with mutations each at each genomic loci by histological classification
| Mutation | Loci | Tumor suppressor genes (TSG) | The percent of microdissected targets with LOH and MSI mutations at each loci in each Histological Classification | |||||
|---|---|---|---|---|---|---|---|---|
| % COL N = 99 |
% IM N = 427 |
% IND N = 182 |
% LGD N = 85 |
% HGD N = 61 |
% EAC N = 23 |
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| MSI | 1p | CMM1, LMYC | 1 | – | 2 | 1 | 7 | 9 |
| 3p | VHL, OGG1 | – | 7 | 3 | 11 | 13 | 3 | |
| 5q | MCC, APC | – | 3 | 3 | 7 | – | 4 | |
| 9p | CDKN2A | 2 | 2 | – | 1 | 13 | – | |
| 10q | PTEN, MXI1 | – | 1 | 3 | 2 | 10 | 9 | |
| 17p | TP53 | – | 4 | 2 | 7 | 7 | 9 | |
| 17q | NME1 | – | 2 | 3 | 14 | 11 | 4 | |
| 18q | DCC | – | 5 | 1 | 1 | 10 | 4 | |
| 21q | TFF1, PSEN2 | – | 3 | – | 1 | – | – | |
| 22q | NF2 | – | 2 | – | 4 | 5 | 4 | |
| LOH | 1p | CMM1, LMYC | 1 | 5 | 14 | 19 | 34 | 43 |
| 3p | VHL, OGG1 | 2 | 5 | 18 | 27 | 41 | 61 | |
| 5q | MCC, APC | 11 | 8 | 18 | 20 | 34 | 61 | |
| 9p | CDKN2A | 7 | 32 | 36 | 45 | 72 | 61 | |
| 10q | PTEN, MXI1 | 10 | 7 | 22 | 8 | 15 | 43 | |
| 17p | TP53 | 11 | 11 | 29 | 49 | 87 | 83 | |
| 17q | NME1 | 2 | 7 | 22 | 26 | 21 | 65 | |
| 18q | DCC | – | 1 | 1 | 11 | 38 | 78 | |
| 21q | TFF1, PSEN2 | 5 | 5 | 12 | 24 | 21 | 13 | |
| 22q | NF2 | – | 2 | 1 | 5 | 15 | 48 | |
COL columnar mucosa, IM intestinal metaplasia, IND indefinite for dysplasia, LGD low-grade dysplasia, HGD high-grade dysplasia, EAC esophageal adenocarcinoma, – 0 % targets mutated