Table 3.

Associations between family history of colorectal cancer in first- and second-degree relatives and colorectal cancer cases with a BRAF p.V600E mutation

				ALL			MMR-proficient			MMR-deficient
		All	BRAF wildtype	BRAF mutated	OR (95% CI)*	p-value	BRAF mutated	OR (95% CI)*	p-value	BRAF mutated	OR (95% CI)*	p-value
FDR with CRC	no	530	483	47	ref		39	ref		8	ref
	yes	160	154	6	0.41 (0.17–0.99)	0.05	5	0.43 (0.16–1.11)	0.08	1	0.34 (0.04–2.76)	0.31
SDR with CRC	no	454	414	40	ref		35	ref		5	ref
	yes	236	223	13	0.62 (0.32–1.19)	0.15	9	0.50 (0.23–1.07)	0.08	4	1.43 (0.38–5.43)	0.60
FDR or SDR with CRC	no	359	324	35	ref		31	ref		4	ref
	yes	331	313	18	0.55 (0.30–1.00)	0.05	13	0.46 (0.24–0.91)	0.03	5	1.20 (0.32–4.53)	0.79
FDR or SDR with CRC	no	359	340	35	ref		31	ref		4	ref
	FDR alone	95	91	5	0.53 (0.20–1.40)	0.20	4	0.50 (0.17–1.46)	0.20	1	0.79 (0.09–7.29)	0.84
	SDR alone	171	162	12	0.73 (0.36–1.42)	0.34	8	0.56 (0.25–1.25)	0.15	4	2.01 (0.49–8.22)	0.33
	both FDR and SDR	65	65	1	0.15 (0.02–1.12)	0.06	1	0.18 (0.02–1.33)	0.10	0

^*adjusted for sex and age at diagnosis

≠ per person

FDR with CRC = family history of first-degree relatives with colorectal cancer

SDR with CRC = family history of second-degree relatives with colorectal cancer

FDR or SDR with CRC = family history of first- or second-degree relatives with colorectal cancer