Fig. 10.

VKO mice exhibit an increase of basement membrane in the sinusoids. To further understand changes in sinusoid endothelial cells, we analyzed the basement membrane marker laminin. VKO mice demonstrated a dramatic abundance of laminin (C and D) compared with littermate controls (A and B) at P30. Laminin was increased primarily around the CV in the surrounding sinusoid endothelial cells. Slides were counterstained with Mayer's hematoxylin. Scale bar is 200 μm (A and C) and 50 μm (B and D).