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. 2014 May 6;5:3777. doi: 10.1038/ncomms4777

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Image showing the two principal methods for adding additional solvent/reagent to a flowing droplet stream: (a) droplet fusion, in which a second droplet stream containing the new solvent/reagent is merged on a pairwise basis with the original droplet stream, using an applied voltage or specially engineered channel structure18; and (b) direct injection, in which the new solvent/reagent is introduced as a continuous stream that directly inserts into the droplets.