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. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Cancer Cell. 2014 Feb 10;25(2):133–134. doi: 10.1016/j.ccr.2014.01.027

Figure 1. PKCι-Dependent Activation of the HH Pathway.

Figure 1

(A) PKCι phosphorylates and activates GLI1 to amplify target gene expression in basal cell carcinoma (BCC), a cell-intrinsic tumor with HH pathway mutations in PTCH1 or SMO. Blue denotes inactive protein, whereas red is active.

(B) PKCι promotes HHAT-mediated HH ligand production by phosphorylating and activating SOX2, which binds to the HHAT promoter in HH-driven autocrine/paracrine lung squamous cell carcinoma (LSCC) tumors.