Skip to main content
. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Chem. 2014 Jan 19;6(2):133–140. doi: 10.1038/nchem.1844

Figure 1. Strategic overview of NP families selected for library expansion and corresponding scaffold selection.

Figure 1

Each family of NPs is exemplified by 2–3 members and the biological activities cited are representative of each family as a whole. The reviews30-35 provide overviews of the biological landscape, with additional references provided in Supplementary Table 1. In each case, a primary scaffold embodies the minimal structural aspects of the NP family that were pursued. These involved removal of some features to enhance both versatility and synthetic accessibility. Secondary scaffolds (far right) represent more substantially modified variants of the primary scaffold, either through functional group or substitution changes or modification of ring structures.