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. 2014 Apr 28;111(19):E2008–E2017. doi: 10.1073/pnas.1402944111

Fig. 7.

Fig. 7.

Gross, MRI, and surgical images of sciatic nerve PNI by cancer cells lacking GFRα1 maintaining an ability to invade nerves. (A–D) Representative mice bearing no tumor, Mia shControl tumor, Mia shGFRα1 tumor, or Mia shRET tumor, respectively, in the right sciatic nerve at the indicated time points. The Mia shControl and Mia shGFRα1 mice demonstrate right hind limb paralysis, whereas the Mia shRET and normal mice have intact hind limb function. (E–H) Representative T2-weighted MRI images of mice. The Mia shControl and Mia shGFRα1 tumors demonstrate thickened sciatic nerves (arrows), whereas the Mia shRET tumor and non–tumor-bearing animal show normal caliber sciatic nerves (arrows). (I–L) Representative sciatic nerves at sacrifice with tumor exposure. The Mia shControl and Mia shGFRα1 tumors (asterisks) both demonstrate thickened and invaded sciatic nerves, with the Mia shGFRα1 nerves less severely infiltrated. In contrast, Mia shRET tumor (asterisk) and non–tumor-bearing animal show normal caliber sciatic nerves.