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A tissue microarray of 141 surgically excised human pancreatic ductal adenocarcinomas, in which PNI is nearly ubiquitous, was assessed by immunohistochemistry for cancer cell GFRα1 expression. (A–C) Representative sections of GFRα1 0 (A), 1+ (B), and 2+ (C) specimens are shown. (D) Wide variance in expression was noted, with 52 cases staining 0 (negative), 67 cases stained 1+ (mild to moderately positive), and 22 cases stained 2+ (strongly positive).
