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UNC93B1 is essential for TLR5-mediated signaling in vivo. (A and B) WT and UNC93B1-deficient mice (n = 3 each) were injected i.p. with 1 μg of flagellin. (A) The serum levels of IL-6 and IL-12p40 were measured by ELISA (mean ± SD). (B) Six hours later, splenocytes were collected and the levels of CD40, CD80, and CD86 in CD11chigh DCs were analyzed by flow cytometry.
