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. 2014 May 6;9(Suppl 1):33–49. doi: 10.2147/IJN.S51842

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© 2014 Jalani et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Decoupled in vitro drug release kinetics from the dual drug-loaded bicompartmental nanofibers composed of poly(NIPAM-co-SA) and PEGDMA compartments at various temperatures.

Notes: Two different sets of the dual drug-loaded bicompartmental nanofibers were prepared: (A) a BSA-loaded poly(NIPAM-co-SA) compartment and a DMP-loaded PEGDMA compartment; and (B) a DMP-loaded poly(NIPAM-co-SA) compartment and a BSA-loaded PEGDMA compartment. The different sets of the dual drug-loaded nanofiber solutions were maintained in a suspension state at 4°C or 37°C to observe the temperature-controlled drug release. The BSA from the BSA-loaded poly(NIPAM-co-SA) compartment was released at a slower rate at 37°C compared to 4°C because aggregation of the poly(NIPAM-co-SA) chains at 37°C caused the hydrated pore size of the poly(NIPAM-co-SA) compartment to become smaller, trapping BSA within the physically-crosslinked poly(NIPAM-co-SA) compartment.

Abbreviations: poly(NIPAM-co-SA), poly(N-isopropylacrylamide-co-stearyl acrylate); BSA, bovine serum albumin; PEGDMA, polyethylene glycol dimethacrylates; DMP, dexamethasone 21-phosphate.