Fig. 1.

Plasma glucose (A) and insulin (B) levels in response to the frequently sampled intravenous glucose tolerance test. Glucose (0.3 g/kg) is injected over 1 min at time (t) = 0, and insulin (0.03 U/kg) is injected over 30 s at t = 20 min. Intravenous glucose tolerance improved in type 1 diabetes (T1D) from pre- to posttransplant (P < 0.01), with posttransplant glucose disappearance not different from normal. The acute insulin response to the injection of glucose, which was absent in T1D pretransplant, was restored posttransplant to levels comparable to normal.