Table 1.
Demographic data, median (range), at the time of data collection
| Demographics | Tac C0 group n = 123 |
CsA C2 group n = 54 |
|---|---|---|
| Male/female (n) | 87/36 | 41/13 |
| Age, years | 48 (20–79) | 60 (21–81) |
| Height (m) | 1.75 (1.54–2.06) | 1.76 (1.55–1.90) |
| Weight (kg) | 74.2 (43.6–158.0) | 76.7 (46.9–118.0) |
| BMI (kg/m2) | 24.7 (16.4–40.7) | 24.4 (19.5–38.9) |
| Diabetes mellitus (n) | 21 | 5 |
| Bilirubin (μmol/L) | 6 (2–15) | 10 (5–25) |
| Treated with dihydropyridine derivatives (n) | 70/123 | 22/54 |
| Treated with statins (n) | 0/123 | 0/54 |
| Treated with glucocorticoids (n) | 123/123 | 54/54 |
| Treated with proton pump inhibitor (n) | 123/123 | 54/54 |
| CNI dose (mg/day) | 3.5 (1.5–9.0) | 175 (100–425) |
| Blood concentration (μg/L) | 7.0 (4.1–13.8) | 1252 (620–3,240) |
| C/D ratioa (μg*L-1/mg) | 2.0 (0.6–5.5) | 7.2 (2.2–16.2) |
| Time after transplantation (days) | 15 (14–31) | 18.5 (14–48) |
BMI body mass index (kg/m2), CNI calcineurin inhibitor
a Steady-state dose-adjusted concentration (C/dose)