Table 2.

Genotype and allele frequencies in the study population (n = 177) compared with allele frequencies reported in the literature

	Genotype frequencies, n (%)			Allele frequencies (%)	Reported allele frequencies in Caucasiansb (%)
	AA	Aa	aa
CYP3A5*3 a	142 (80)	34 (19)	1 (1)	90	81–96
CYP3A4*22	168 (95)	9 (5)	0 (0)	3	3–6c
PPARA c.209-1003G>A	108 (61)	59 (33)	10 (6)	22	21–24
PPARA c.208 + 3819A>G	100 (56)	63 (36)	14 (8)	26	25–26
POR*28	82 (46)	78 (44)	17 (10)	32	28–31

AA homozygote carriers of the major allele, Aa heterozygote carriers, aa homozygote carriers of the minor (variant) allele

^aVariant allele is predominant in Caucasians

^b http://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/

^cAllele frequency based on published studies [14, 17–19, 31, 32]