Table 3.
Tacrolimus and cyclosporine median C/D ratios in different genotypes
| Tac C0/D ratio (μg*L-1/mg) | n | CsA C2/D ratio (μg*L-1/mg) | n | |
|---|---|---|---|---|
| CYP3A5*3 | ||||
| *1/*1 | - | 0 | 6.89 | 1 |
| *1/*3 | 1.38 (0.61, 3.67) | 27 | 7.62 (6.53, 10.93) | 7 |
| *3/*3 | 2.37 (0.98, 5.47) | 96 | 7.16 (2.24, 16.20) | 46 |
| CYP3A4*22 | ||||
| *1/*1 | 2.03 (0.61, 5.47) | 117 | 7.11 (2.24, 16.20) | 51 |
| *1/*22 | 2.07 (1.30, 4.70) | 6 | 11.12 (8.70, 11.17) | 3 |
| *22/*22 | - | 0 | - | 0 |
| PPARA c.209-1003G>A | ||||
| GG | 1.93 (0.61, 5.47) | 71 | 7.06 (2.46, 16.20) | 37 |
| GA | 2.01 (0.99, 4.73) | 44 | 7.60 (2.24, 11.17) | 15 |
| AA | 3.20 (1.47, 4.70) | 8 | 6.36 (5.48, 7.25) | 2 |
| PPARA c.208 + 3819A>G | ||||
| AA | 1.83 (0.61, 5.47) | 64 | 7.09 (2.46, 16.20) | 36 |
| AG | 2.27 (0.99, 4.73) | 47 | 7.58 (2.24, 11.17) | 16 |
| GG | 2.70 (1.30, 4.70) | 12 | 6.36 (5.48, 7.25) | 2 |
| POR*28 | ||||
| *1/*1 | 2.27 (0.61, 5.47) | 54 | 7.24 (2.24, 11.12) | 28 |
| *1/*28 | 1.88 (0.92, 4.73) | 62 | 6.82 (3.54, 16.20) | 16 |
| *28/*28 | 1.95 (1.11, 3.40) | 7 | 7.98 (4.87, 11.17) | 10 |
Data are presented as median (range) unless otherwise stated