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. 2013 Jun 9;5(1):3–13. doi: 10.1111/jdi.12106

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Copyright © 2014 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd

© 2013 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Strategy for preventing the progression of atherosclerosis in diabetic patients. The development and progression of atherosclerosis in diabetic patients are significantly affected by: (i) metabolic abnormalities associated with chronic hyperglycemia; (ii) a complex of risk factors related to insulin resistance and visceral fat accumulation; and (iii) postprandial hyperglycemia. Previous studies showed that drugs improving insulin resistance were more effective in reducing carotid intima‐media thickness (IMT) progression as compared with other types of antidiabetic drugs, and that drugs that ameliorate postprandial hyperglycemia potently attenuated carotid IMT progression. Besides being a useful marker of the progression of subclinical atherosclerosis and a good predictor of cardiovascular events, carotid IMT can be used to evaluate the efficacy of various treatments. CVD, cardiovascular disease; US; ultrasonography.