Figure 1.

Conserved negative cell-cycle regulators were identified in the Elm screen. (A) Schematic diagram of genome-wide RNA interference (RNAi) screen. RNAi feeding clones were independently tested for the ability to transform the progeny of lin-12(gf) multivulva (Muv) animals into Elm animals that display greater than six pseudovulvae. (B) Pie chart illustrating the distribution of the predicted functions for the 107 genes identified by the Elm screen. (C) Venn diagram of 107 genes identified by the genome-wide RNAi screen as potential cell-cycle quiescence regulators. Thirteen genes overlap between the 33 genes also necessary for restricting cell cycles in the intestine and the 47 genes listed on OrthoList.