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. 2014 Feb 28;4(5):795–804. doi: 10.1534/g3.114.010546

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Copyright © 2014 Roy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genetic redundancy ensures strict control of cell-cycle quiescence. (A) Box and whisker plot presenting the effect of RNA interference (RNAi)-mediated inhibition of ubc-1, ubc-17, ubc-20, and ubc-21 on intestinal nuclei number in wt and ubc-25(ok1732) animals. ubc-3(RNAi) illustrates an example of an ubc gene that does not display redundancy. (B) B0393.6(RNAi) significantly enhanced the number of intestinal nuclei of ubc-25(ok1732), lin-36(n766) and cdc-14(he141) mutant animals, indicating a fourth distinct genetic pathway promoting cell-cycle quiescence. Statistical significance was determined by comparing test RNAi animals to the RNAi of the negative control gene, unc-73, using the two-tailed Student t-test (*P < 0.05 and **P < 0.01). n ≥ 15 animals examined for each condition.