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. 2014 Mar 17;4(5):885–890. doi: 10.1534/g3.114.010355

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Copyright © 2014 Doray et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Growth retardation of Gga2^−/− mice. (A) Picture of day 1 pups from a single litter of a Tigm Gga2^+/− cross in the mixed genetic background shows that the homozygous knockout has a markedly reduced body size. (B) The male Gga2^−/− mouse (left mouse) in the mixed genetic background is much smaller than its female wt littermate at 6 wk of age but is otherwise healthy. (C) Weights were obtained from week 1 to week 12 and plotted according to gender and genotype. Results shown are mean ± SEM for each time point. Males: wt, n = 7; Gga2^+/−, n = 11; Gga2^−/−, n = 6. Females: wt, n = 3; Gga2^+/−, n = 2; Gga2^−/−, n = 2. P values for pairwise comparisons of mean weights between wt and Gga2^−/− male mice are as follows: *P < 0.05, **P < 0.005, and ***P < 0.0005. NS, not significant. Statistical analysis was not performed with the females due to the small sample size.