Table 3.
Polymorphisms in TNFAIP3 gene and risks of rheumatoid arthritis stratified by age
| Genotype |
≤53 |
>53 |
||||
|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | OR [95% CI] | Cases (%) | Controls (%) | OR [95% CI] | |
| rs2230926 |
|
|
|
|
|
|
| TT |
452(80.7) |
564(88.3) |
1.00 |
620(86.1) |
569(88.8) |
1.00 |
| TG |
104(18.6) |
75(11.7) |
1.73[1.26-2.39] |
96(13.3) |
68(10.6) |
1.30[0.93-1.80] |
| GG |
4(0.7) |
0(0.0) |
— |
4(0.6) |
4(0.6) |
0.92[0.23-3.69] |
| TG/GG |
108(19.3) |
75(11.7) |
1.80[1.31-2.47] |
100(13.9) |
72(12.2) |
1.28[0.92-1.76] |
| rs13207033 |
|
|
|
|
|
|
| GG |
472(84.3) |
528(82.6) |
1.00 |
568(78.9) |
520(81.1) |
1.00 |
| GA |
84(15.0) |
107(16.7) |
0.88[0.64-1.20] |
148(20.6) |
109(17.0) |
1.24[0.95-1.64] |
| AA |
4(0.7) |
4(0.6) |
1.12[0.28-4.50] |
4(0.6) |
12(1.9) |
0.31[0.10-0.95] |
| GA/AA |
88(15.7) |
111(17.4) |
0.89[0.65-1.20] |
152(21.1) |
121(18.9) |
1.15[0.88-1.50] |
| rs10499194 |
|
|
|
|
|
|
| CC |
499(89.1) |
600(93.9) |
1.00 |
657(91.3) |
615(95.9) |
1.00 |
| CT |
60(10.7) |
38(5.9) |
1.89[1.24-2.90] |
60(8.3) |
25(3.9) |
2.25[1.39-3.63] |
| TT |
1(0.2) |
1(0.2) |
1.20[0.08-19.27] |
3(0.4) |
1(0.2) |
2.81[0.29-27.07] |
| CT/TT | 61(10.9) | 39(6.1) | 1.88[1.24-2.86] | 63(8.7) | 26(4.1) | 2.27[1.42-3.63] |