Table 2.
Results of area under the curve of CGM and glucose fluctuations at STEP 0 and at the end of this protocol
| At the evaluation of STEP 0 | At the end of this protocol | |
|---|---|---|
|
Results of continuous glucose monitoring |
|
|
| Number of patients |
14 |
14 |
| AUC for 24-h glycemic fluctuation (mg・h/dL) |
4112.1 |
2986.3* |
| (3568.8-4338.5) |
(2843.3-3504.0) |
|
| AUC for 4-h after breakfast glycemic fluctuation (mg・h/dL) |
732.3 |
521.5* |
| (607.4-845.4) |
(498.9-626.9) |
|
| AUC for 4-h after lunch glycemic fluctuation (mg・h/dL) |
785.9 |
516.2* |
| (573.5-952.0) |
(466.5-550.6) |
|
| AUC for 4-h after dinner glycemic fluctuation (mg・h/dL) |
785.3 |
559.2* |
| (719.4-877.8) |
(485.3-651.4) |
|
| AUC for 8-h from midnight to early morning glycemic fluctuation (00:00–08:00) (mg・h/dL) |
1033.0 |
949.8 |
| (911.4-1187.5) |
(869.6-1074.3) |
|
| 24-h mean glucose levels (mg/dL) |
169.7 |
124.7* |
| (142.6-181.1) |
(118.8-146.4) |
|
| SDs of 288 glucose levels for 24-h (mg/dL) |
38.6 |
23.5* |
| (29.9-58.5) |
(13.9-28.4) |
|
| Proportion of time (%) in hyperglycemia (>180 mg/dL) |
40.7 |
7.9* |
| (17.4-53.7) |
(0–17.2) |
|
| Proportion of time (%) in hypoglycemia (<70 mg/dL) |
0 |
0 |
| MAGE |
91.1 (79.1-119.6) |
61.3* (50.2-72.4) |
|
Results of 7-point SMBG |
|
|
| Number of patients |
16 |
16 |
| M-value | 28.8 (21.4-52.5) | 8.7 *(5.0-15.7) |
Median (interquartile range)
*P < 0.05
CGM data were analyzed in a total of 14 patients because of missing CGM data in 2 of the 16 patients.