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. 2014 Jun 1;20(16):2621–2630. doi: 10.1089/ars.2013.5448

FIG. 2.

FIG. 2.

Response of C. elegans to 3-MST deficiency and effect of GYY4137. (A) Effect of cth-2 and mpst-1 RNAi knockdown on lifespan, n=130–288 animals per group, *p<0.05 compared to wild type. (B) Comparison of lifespan in wild-type and mpst-1 (ok2040) null animals and rescue of mpst-1 null animals by GYY4137 (GYY; 100 μM), n=340–516 animals per group, *p<0.05, mpst-1 null versus wild type, +p<0.05 mpst-1 null versus mpst-1 null+GYY4137. (C) Healthspan comparison in wild-type and mpst-1 knockout animals as assessed over 30 days, n=108–149 animals per group, *p<0.05. (D) Spontaneous release of H2S from GYY4137 (100 μM) incubated for up to 30 days at 20°C. Results are mean±SE mean, n=6–9 (where not shown standard error bars lie within dimensions of symbol). (E) Effect of GYY4137 (100 μM) on lifespan of wild-type C. elegans, n=114–123, *p<0.05. (F) Effect of time-expired GYY4137 (100 μM, 10 days at room temperature) on lifespan of C. elegans, n=67–86 animals per group, p>0.05.