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. 2014 Jun 1;20(16):2621–2630. doi: 10.1089/ars.2013.5448

FIG. 4.

FIG. 4.

H2S and markers of oxidative stress in C. elegans. (A) Effect of GYY4137 (GYY; 100 μM) on paraquat-evoked (10 mM) toxicity. Data show median survival assessed daily over a 7-day period, n=154–187, *p<0.05. (B) Effect of GYY4137 (100 μM) treatment on reactive oxygen species (ROS) production determined by MitoSOX Red fluorescence, data show mean±SEM of three independent experiments, *p<0.05. (C) MitoSOX Red fluorescence indicative of ROS production in wild-type (control) and mpst-1 knockout C. elegans, data show mean±SEM of three independent experiments, *p<0.05. (D) Measurement of mtDNA damage in wild type (control), wild type treated with GYY4137 (100 μM), and mpst-1 knockout C. elegans, data show mean±SEM of three independent experiments, *p<0.05. Measurement of protein carbonyl content (PCC) in GYY4137-treated (GYY; 100 μM) wild-type controls (E) and in mpst-1 knockout C. elegans (F), data show mean±SEM, n=10–13, *p<0.05. (G) Effect of GYY4137 (GYY; numbers in parenthesis show concentration in μM) on survival of mev-1 (kn1) C. elegans mutants, n=52–58, *p<0.05.