Table 3.
Adverse events with an incidence ≥ 5% in either treatment group*.
|
Memantine (n = 321) |
Placebo (n = 319) |
|||
|---|---|---|---|---|
| n | % | n | % | |
| Patients with adverse events | 252 | 78.5 | 245 | 76.8 |
| Constipation | 37 | 11.5 | 33 | 10.3 |
| Diarrhea | 14 | 4.4 | 18 | 5.6 |
| Vomiting | 10 | 3.1 | 17 | 5.3 |
| Nasopharyngitis | 46 | 14.3 | 54 | 16.9 |
| Fall | 31 | 9.7 | 33 | 10.3 |
| Contusion | 18 | 5.6 | 20 | 6.3 |
| Dementia Alzheimer's type‡ | 9 | 2.8 | 20 | 6.3 |
| Insomnia | 18 | 5.6 | 16 | 5.0 |
*Adverse events were coded according to preferred term using the Japanese version of the Medical Dictionary for Regulatory Activities version 11.1.
‡Corresponds to worsening of Alzheimer's disease.