Table 1.
Cytokine Production According to Viral Type at Days 1 and 3
| Cytokine/Day | DENV-1 | DENV-2 | DENV-3 | DENV-4 | Control |
|---|---|---|---|---|---|
| Neonatal | |||||
| TNF-α/1 | 63.76±4.25** | 132.1±2.40* | 62.33±3.54** | 65.7±1.95** | 9.57±0.66 |
| TNF-α/3 | 71.34±1.94** | 185.3±3.11* | 78.27±1.62** | 75.8±0.54** | 12.0±0.43 |
| IL-6/1 | 147.9±12.5** | 165.7±5.77** | 140.4±7.51** | 215.2±5.38* | 60.89±5.3 |
| IL-6/3 | 217±2.30** | 219±11.6** | 189±6.32** | 298.3±3.5* | 84.38±4.27 |
| IL-1β/1 | 43.84±0.36** | 145.2±1.64* | 54.59±0.93** | 43.06±0.6** | 11.04±0.33 |
| IL-1β/3 | 56.03±3.24** | 180.6±1.08* | 65.83±2.85** | 62.3±1.19** | 15.35±0.71 |
| Adult | |||||
| TNF-α/1 | 135.9±1.04** | 230.6±1.2* | 130.7±0.86** | 133.5±1.6** | 15.29±0.16 |
| TNF-α/3 | 162.1±2.65** | 261.7±1.03* | 156.6±1.46** | 157±2.77** | 17.26±0.41 |
| IL-6/1 | 279.5±12.7** | 259.4±16.5** | 279±8.59** | 396.7±7.49* | 105.2±1.21 |
| IL-6/3 | 310.8±2.60** | 293.3±4.69** | 314.7±5.23** | 473±21.63* | 122.7±2.29 |
| IL-1β/1 | 74.73±0.7** | 195.5±0.72* | 75.55±1.65** | 77.31±1.2** | 15.95±1.75 |
| IL-1β/3 | 93.59±2.32** | 223.1±1.13* | 86.72±2.41** | 88.17±1.9** | 19.2±0.72 |
| Elderly | |||||
| TNF-α/1 | 85.09±1.38** | 155.2±0.58* | 90.06±1.04** | 86.27±4.3** | 10.04±0.07 |
| TNF-α/3 | 92.29±2.03** | 202.8±4.41* | 98.78±0.81** | 97.8±1.91** | 13.76±0.28 |
| IL-6/1 | 238.3±10.7** | 212.4±6.65** | 243.7±27.3** | 367.1±5.14* | 90.03±2.08 |
| IL-6/3 | 289.4±3.43** | 259.3±7.57** | 286±8.60** | 397.7±4.80* | 111.6±6.43 |
| IL-1β/1 | 71.21±0.94** | 164±0.36* | 63.15±0.69** | 68.96±1.2** | 13.26±0.16 |
| IL-1β/3 | 83.17±0.21** | 213.7±1.14* | 71.63±0.67** | 74.9±1.23** | 17.1±0.81 |
Boldface numbers represent the cytokine high values observed during a particular dengue type infection.
*
p<0.01 versus all other groups; **p<0.001 versus control (uninfected Mo/MΦ cultures).